Sinfest

Since it started, Sinfest has captured attention of many with its wit and humor. It is one of longest going web comics and the only one to feature GOD, the Devil, assorted degenerates, a cat and a dog. It will make you laugh until it hurts.  The primary characters are Slick, a Calvin-esque teenaged "pimp" who's always trying to look as cool as he can, and his hot friend Monique, who spends her days fighting for feminist causes when she isn't flirting with hot guys (of whom Slick doesn't qualify).

Other characters include God and Satan, who still hold a silly grudge; Seymour, a religious zealot; Li'l Evil, a Satan zealot; Squigley, a pig who gets high all the time; Jesus; Buddha; The Dragon, an embodiment of Eastern religion; Percival and Pooch, the artist's cat-and-dog duo; and Criminy, the sheltered bookworm. They have surreal, metaphysical adventures that often involve Slick's high view of himself, Monique's oversexed behavior, Satan's desire to acquire their souls, and other goings-on.